Autodock Vina 112 Download Verified May 2026

Autodock Vina 1.1.2 — verified download

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AutoDock Vina 1.1.2 Download: Verified Legacy Version Guide AutoDock Vina 1.1.2 remains a foundational tool for molecular docking and virtual screening, valued for its high performance and multi-core capability. While a newer version (1.2.x) was introduced in 2021, the legacy 1.1.2 version is still widely cited in research and used in established computational pipelines. Official and Verified Download Sources

To ensure you are downloading a safe and verified version of AutoDock Vina 1.1.2, use the following reputable sources:

The Scripps Research Institute (Official Legacy Site): The primary source for the 1.1.2 legacy version is the Official Vina Website. This site is maintained for informational purposes and provides access to the original 2011 binaries.

SourceForge (64-bit Binaries): For 64-bit systems, a verified repository of binaries is available on SourceForge. This includes versions for Windows, Linux, and macOS.

Bioconda: For Linux users using the Conda package manager, AutoDock Vina 1.1.2 can be installed via the Bioconda channel using the command conda install -c bioconda autodock-vina. Key Features of Version 1.1.2

AutoDock Vina 1.1.2 revolutionized molecular docking by offering: PubMed Central (PMC) (.gov)https://pmc.ncbi.nlm.nih.gov

AutoDock Vina 1.1.2 is considered a legacy version (originally released in 2011). While the current stable release is version 1.2.x, version 1.1.2 is still widely available through official academic archives for those who need to maintain compatibility with older research protocols. AutoDock Vina 1. Verified Download Sources autodock vina 112 download verified

To ensure you are downloading a safe and authentic version, only use the official Scripps Research portals: Official Legacy Page: AutoDock Vina Downloads

page provides direct links for Linux, macOS, and Windows versions of 1.1.2. Official GitHub:

For the most up-to-date source code or "modernised" versions that compile with newer libraries, visit the ccsb-scripps GitHub Repository For Linux/Mac users, version 1.1.2 can be installed via the Anaconda/Bioconda package manager. AutoDock Vina 2. Step-by-Step Installation Guide For Windows Users autodock_vina_1_1_2_win32.msi installer from the official site Run Installer: Double-click the file and follow the prompts. It typically installs to C:\Program Files (x86)\The Scripps Research Institute\Vina\ Environment Variables (Optional but Recommended): Open "Edit the system environment variables." Add the Vina installation folder to your so you can run from any command prompt. AutoDock Vina For Linux Users autodock_vina_1_1_2_linux_x86.tgz Open your terminal and run: tar xzvf autodock_vina_1_1_2_linux_x86.tgz Use code with caution. Copied to clipboard The executable will be in the folder. You can move it to /usr/local/bin to make it globally accessible. AutoDock Vina For macOS Users autodock_vina_1_1_2_mac_64bit.tar.gz Use the terminal: tar xzvf autodock_vina_1_1_2_mac_64bit.tar.gz Use code with caution. Copied to clipboard Security Note:

Modern macOS versions may block the executable because it is "unsigned." You may need to go to System Settings > Privacy & Security to "Allow Anyway" after the first attempt to run it. AutoDock Vina 3. Mandatory Prerequisites AutoDock Vina

is a command-line tool. To actually prepare your molecules and see the results, you also need: AutoDock Vina

AutoDock Vina 1.1.2 is the legacy version of the popular molecular docking software, originally released in May 2011. While newer versions like Vina 1.2.x are now standard, 1.1.2 remains a foundational tool for structure-based drug design and virtual screening. Verified Download Sources

To ensure a secure and authentic download, use the following official or long-standing community repositories:

Official Scripps Resource Site: The legacy site dedicated to v1.1.2 is available at The Scripps Research Institute.

SourceForge (Legacy Binaries): A common community repository for the 64-bit binaries of v1.1.2 is hosted on SourceForge.

GitHub (Latest Versions): For the most up-to-date stable versions (1.2.x and beyond), the project has moved to the CCSB-Scripps GitHub. Available Versions for 1.1.2 Autodock Vina 1

The following pre-compiled binaries are typically available for version 1.1.2: Windows: autodock_vina_1_1_2_win32.msi Linux: autodock_vina_1_1_2_linux_x86.tgz

macOS: autodock_vina_1_1_2_mac_64bit.tar.gz and autodock_vina_1_1_2_mac.tgz (32-bit) Installation Overview

Extract/Install: Download the appropriate package for your OS. Windows users run the .msi installer, while Linux and Mac users should extract the .tar.gz or .tgz files to a preferred directory.

Environment Setup: It is recommended to add the Vina folder path to your Environment Variables (PATH) so you can run the vina command from any terminal or command prompt.

Dependencies: Vina 1.1.2 is a "turnkey" program that does not require pre-calculating grid maps, but it is often used alongside MGLTools (specifically AutoDock Tools) to prepare receptor and ligand .pdbqt files. Why Version 1.1.2? AutoDock Vina

The verified legacy version of AutoDock Vina 1.1.2 can be downloaded directly from the Scripps Research Institute's official downloads page . While this version remains available for historical and comparative purposes, the GitHub repository is now the primary source for the latest stable releases (v1.2.x), which include expanded features and bug fixes.

The Evolution and Impact of AutoDock Vina in Computational Drug Discovery

Molecular docking has fundamentally shifted the paradigm of drug discovery, moving it from labor-intensive "wet lab" trial-and-error to a sophisticated, predictive computational science. At the heart of this transformation is AutoDock Vina , an open-source program that has become the gold standard for predicting how small molecules interact with biological targets. Since its initial release in 2010 by Dr. Oleg Trott and the Molecular Graphics Lab at The Scripps Research Institute, Vina has balanced three critical pillars: speed, accuracy, and ease of use. Technical Foundations: Scoring and Optimization

AutoDock Vina’s success stems from its unique hybrid scoring function and efficient optimization algorithm. Unlike its predecessor, AutoDock 4, which relied heavily on physics-based terms like van der Waals and Coulomb energies, Vina utilizes an empirical approach inspired by machine learning. It extracts information from both conformational preferences and experimental affinity measurements to better correlate with real-world binding affinities.

Complementing this scoring function is an "Iterated Local Search" global optimizer. By employing the Broyden-Fletcher-Goldfarb-Shanno (BFGS) method for local optimization, Vina calculates gradients that give the algorithm a "sense of direction". This allows the program to achieve a speed-up of approximately two orders of magnitude compared to previous versions while simultaneously improving prediction accuracy. Integrity checks performed:

AutoDock Vina 1.1.2 has no known remote execution vulnerabilities in the distributed binary. However, best practice includes:

If your checksum does not match exactly, delete the file immediately. It is corrupt or tampered.

AutoDock Vina 1.1.2 can be downloaded and verified securely by:

Following this verified download procedure ensures that your molecular docking workflow is based on authentic, untampered software, maintaining scientific reproducibility and system security.

References:

In the rapidly evolving world of computational chemistry and structure-based drug design, AutoDock Vina has maintained its status as a gold standard for molecular docking. Developed by The Scripps Research Institute, Vina is celebrated for its speed, accuracy, and user-friendly command-line interface.

Among its many iterations, AutoDock Vina 1.1.2 holds a special place. While newer versions (1.2.x and above) introduce features like support for macrocycles and covalent ligands, version 1.1.2 remains the most cited, validated, and trusted release for standard small-molecule docking. It is lightweight, stable, and compatible with nearly all downstream analysis tools (like AutoDock Tools, PyMOL, and PLIP).

However, the internet is rife with outdated links, unofficial builds, and potentially hazardous binaries. Searching for an "autodock vina 112 download verified" is not just about finding a file—it is about ensuring integrity, security, and reproducibility of your research.

This article provides a step-by-step guide to obtaining a verified copy of AutoDock Vina 1.1.2, along with installation tips, common pitfalls, and verification methods.