This is the single most noticeable upgrade. The E2160 era was dominated by slow 5400RPM IDE or SATA I hard drives.
The absolute biggest performance gain for an E2160 system is swapping the spinning hard drive for a SATA II SSD (e.g., Kingston A400 or Samsung 860 EVO). intel pentium dual cpu e2160 upgrade
Do not spend money upgrading this CPU within the same motherboard. This is the single most noticeable upgrade
The Intel Pentium E2160 is a relic from 2007. While it was a legendary budget workhorse in its heyday, it is now severely obsolete. If you are still running this processor, your computer is likely struggling to browse modern websites, let alone run modern software. The absolute biggest performance gain for an E2160
The only logical "upgrade" is a full platform replacement (Motherboard, CPU, and RAM). Attempting to find a "better" CPU for your current motherboard is throwing good money after bad.