The episode’s title refers to the defining plot reveal. For years within the series, the Ope Ope no Mi was considered the "Ultimate Devil Fruit." Episode 722 finally explains why.
Through dialogue between Doflamingo and his defeated executive, Trebol, as well as Doflamingo’s monologues, the audience learns that the fruit possesses the ability to perform the "Perennial Youth Operation" (Immortality Surgery). A user of the Ope Ope no Mi can grant eternal youth to another person at the cost of their own life.
Doflamingo reveals that he originally wanted the fruit not for its combat abilities, but to perform this surgery on himself (or someone of value) to destabilize the world order. This revelation adds tragic depth to Law’s character—he possesses a power that marks him for death simply by existing, and he chooses to use that power not for immortality, but for vengeance.
No. One Piece Episode 722 is entirely canon (based directly on Chapter 778 and 779 of the manga). However, Toei Animation does add some extended reaction shots and running sequences to pad the runtime. If you are a purist, you won't find major filler content here, but you will find the pacing slightly stretched compared to reading the manga.
Why should you watch One Piece Episode 722 even if you have seen the larger fights? Because this episode focuses on three specific Shonen themes:
“Toko, close your eyes,” Hyogoro orders, but the girl is already staring, her permanent smile wavering. One Piece Episode 722
Zoro lowers Wado Ichimonji. “Killer. I don’t know what they did to you. But I remember the man who laughed at a banquet with his captain. I won’t kill you.”
Killer laughs—a wretched, cracking sound. “Too late for mercy.”
He bites down on the hilt of his fallen sword with his teeth and lunges with his remaining arm. It’s a desperate, foolish attack. Zoro catches the blade between two fingers, an inch from his throat.
“I said I won’t kill you.” Zoro headbutts him. Killer crumples unconscious.
Zoro turns to Hyogoro. “Take him. Hide him. When the smoke clears, tell him… Luffy is coming. And so is his captain.” The episode’s title refers to the defining plot reveal
The episode ends with a wide shot: Zoro standing alone on the shattered bridge, the purple gas swirling around his feet but never touching him. He raises Sandai Kitetsu to the moonlight, watching the cursed blade gleam.
Zoro (internal monologue): “A mind broken by lies, a body turned into a weapon. That’s not a shadow. That’s a warning. Orochi, Kaido… I’m coming for both of you.”
Post-Credits Scene:
Inside the Shogun’s palace, Orochi sits on a golden throne, sipping sake. A ninja kneels before him.
“Kamazo has fallen, my lord.”
Orochi laughs, his multiple heads drooling. “Fallen? No, no, no. He’s delivered my message. Tell Kaido… the Straw Hats have drawn their blades on Wano soil. The game begins.”
The screen cuts to black.
Title Card: Next Episode: 723 — A Man’s Promise: The Fire Festival’s Secret!
End Theme — a melancholic shamisen cover of "We Are!" plays over scenes of Zoro bandaging Killer’s wounds in a hidden cellar, Hyogoro praying to a small shrine of Oden, and a single sakura petal falling onto Zoro’s shoulder.
END of Episode 722.
The action sequences in this episode are visceral. We see Law using his ultimate technique, "Gamma Knife." The animation emphasizes the internal damage Law inflicts on Doflamingo, destroying his organs. Doflamingo’s counter—a grotesque use of his Ito Ito no Mi (String-String Fruit) to stitch his own internal organs back together—is displayed with horrific clarity.
This moment highlights the difference between the two men: Law fights with calculated precision and a death wish, while Doflamingo fights with the arrogance of a Celestial Dragon who refuses to fall to those he considers "commoners."
