Resident Evil 4 - Disc 2 - Romsmania -

Capcom’s decision to split the game was driven by asset density. Disc 2 contains:

When using a ROM of Disc 2 independently, emulators (Dolphin, RetroArch) must handle “disc swapping” via virtual drive changes. RomsMania typically provides Disc 2 as a separate .gcm or .iso file. If a user lacks Disc 1’s save state, they cannot access Disc 2’s content directly—unlike modern all-in-one digital releases. This fragmentation means RomsMania’s Disc 2 ROM is functionally incomplete without its counterpart. Resident Evil 4 - Disc 2 - RomsMania

Most games on RomsMania are listed as single files. For multi-disc games, look for: Capcom’s decision to split the game was driven

Warning: Some uploads merge both discs into one ISO. Always read the file name. If it says “RE4_Disc2.iso” or “RE4_GameCube_Disc2.gcm,” you have the correct file. Warning: Some uploads merge both discs into one ISO

Your Disc 2 ROM may be corrupted. Solution: Re-download from RomsMania and verify the MD5 checksum. A healthy GameCube Disc 2 should have MD5: a1b2c3d4e5f67890... (check Reddit for current hash).